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The last A-6E Intruder left U. Marine Corps service on 28 April The A-6 also saw further duty over Bosnia in The last Intruders were retired on 28 February Many in the US defense establishment in general, and Naval Aviation in particular, questioned the wisdom of a shift to a shorter range carrier-based strike force, as represented by the Hornet and Super Hornet, compared to the older generation aircraft such as the Intruder and Tomcat.

At the time of retirement, several retired A-6 airframes were awaiting rewinging at the Northrop Grumman facility at St. Augustine Airport , Florida; these were later sunk off the coast of St.

Johns County , Florida to form a fish haven named "Intruder Reef". The eight prototypes and pre-production Intruder aircraft were sometimes referred to with the YA-6A designation.

DIANE consisted of multiple radar systems: It suffered numerous teething problems, and it was several years before its reliability was established.

Total A-6A production was , excluding the prototype and pre-production aircraft. Navy squadrons with a defense suppression aircraft to attack enemy antiaircraft defense and SAM missile systems, a mission dubbed " Iron Hand " by the U.

Navy, 19 A-6As were converted to A-6B version during to Five were lost to all causes, and the survivors were later converted to A-6E standard in the late s.

One of these aircraft was lost in combat, the others were later converted to A-6E standard after the war. The DIANE system was removed and an internal refueling system was added, sometimes supplemented by a D refueling pod on the centerline pylon.

Because it was based on a tactical aircraft platform, the KA-6D provided a capability for mission tanking, the ability to keep up with strike packages and refuel them in the course of a mission.

A few KA-6Ds went to sea with each Intruder squadron. These aircraft were always in short supply, and frequently were "cross decked" from a returning carrier to an outgoing one.

Many KA-6 airframes had severe G restrictions, as well as fuselage stretching due to almost continual use and high number of catapults and traps. The definitive attack version of the Intruder with vastly upgraded navigation and attack systems, introduced in and first deployed on 9 December TRAM also allowed the Intruder to autonomously designate and drop laser-guided bombs.

In addition, the Intruder used Airborne Moving Target Indicator AMTI , which allowed the aircraft to track a moving target such as a tank or truck and drop ordnance on it even though the target was moving.

Also, the computer system allowed the use of Offset Aim Point OAP , giving the crew the ability to drop on a target unseen on radar by noting coordinates of a known target nearby and entering the offset range and bearing to the unseen target.

This added the ability to carry and target some of the first generation precision guided weapons, like the AGM Harpoon missile, and AGM Skipper.

The new wings proved to be a mixed blessing, as a composite wing is stiffer and transmits more force to the fuselage, accelerating fatigue in the fuselage.

In , the decision was made to terminate production of the A Through the s and s, the A-6 had been in low-rate production of four or five new aircraft a year, enough to replace mostly accidental losses.

The final production order was for 20 aircraft of the SWIP configuration with composite wings, delivered in Two additional wing pylons were added, for a total of seven stations.

Although five development aircraft were built, the U. This left the service in a quandary when the A was canceled in Marine Corps squadrons in Vietnam.

The last EA-6A had been retired by A much more highly specialized derivative of the Intruder was the EA-6B Prowler , having a "stretched" airframe with two additional systems operators, and more comprehensive systems for the electronic warfare and SEAD roles.

In total, were produced. The EA-6B took on the duties of the U. Depression is marked by altered connectivity, in particular between the anterior cingulate cortex and several other limbic areas, such as the hippocampus.

Additional preclinical and clinical data, suggest that Substance P [SP] and IL-6 may act in concert to promote major depression.

SP, a hybrid neurotransmitter-cytokine, is co-transmitted with BDNF through paleo-spinothalamic circuitry from the periphery with collaterals into key areas of the limbic system.

SP and IL6 both relax tight junctions of the blood brain barrier, such that effects seen in fMRI experiments with these molecules may be a bidirectional mix of neuronal, glial, capillary, synaptic, paracrine, or endocrine-like effects.

The IL-6 antibody sirukumab is now undergoing clinical trials against major depressive disorder. Obesity is a known risk factor in the development of severe asthma.

Recent data suggests that the inflammation associated with obesity, potentially mediated by the cytokine IL6, plays a role in causing poor lung function and increased risk for developing asthma exacerbations.

From Wikipedia, the free encyclopedia. IL6 Gene location Human Chr. Chromosome 7 human [1]. Exercise and Sport Sciences Reviews.

Journal of Applied Physiology. Compr Physiol 3 3: The Journal of Physiology. Claus Brandt and Bente K. Journal of Biomedicine and Biotechnology.

Volume , Article ID , 6 pages. Muscle as an endocrine organ: Focus on muscle-derived interleukin The Journal of Biological Chemistry.

The interleukin-6 receptor can serve as an alpha-receptor for CTNF". Expert Opinion on Investigational Drugs.

Polski Merkuriusz Lekarski in Polish. Current Opinion in Rheumatology. Expert Opinion on Therapeutic Targets. Annals of the Rheumatic Diseases.

International Journal of Molecular Sciences. International Journal of Oncology. International Journal of Cancer. The Journal of Neuroscience.

Archives of General Psychiatry. Biochimica et Biophysica Acta. Brain, Behavior, and Immunity. The American Journal of Psychiatry. Alice and Neil discuss the psychological pressures of going to university.

They also teach some related vocabulary. Neil and Alice discuss the long-lasting appeal of this man with a bow and how he has changed over the centuries.

Do you know how much your partner earns? Is he or she in debt? Would this make you love them less? Should we all pay for supermarket plastic bags?

Neil and Alice take a look at the environmental impact of plastic and teach you some related words. The bicycle is the most popular form of two-wheeled transport in the world, but could we all soon be using hoverboards?

If you are sitting at a desk or answering the phone, stop for a moment and ask: Neil and Finn discuss the future of our jobs. Neil and Alice discuss what kind of book people like to be seen reading.

Do you like to impress people with a classic book in your hands? Do you dress formally or casually? Do you choose trendy items or old comfortable ones?

Rob and Will talk about the meaning of clothes. What an awful sound - cracking your knuckles! Was Charles Darwin the only man with ideas about evolution?

Rob and Neil talk about someone else who discovered it first. What are the modern day dilemmas in using a lift?

Rob and Neil discuss the awkwardness and irritation of being in one. Should young people be made to vote in elections or should we choose?

We discuss the ideas behind compulsory voting. What do we need our chins for? Rob and Neil discuss how we got them and what our chins say about us.

Listen to Neil and Rob discussing mood swings, risk taking, and why people make fun of teenagers, while they also explore some related vocabulary.

How can remote parts of the world get access to the internet? Neil and Catherine discuss a new idea for spreading knowledge. A London apartment block has front and back entrances for private and social housing - or so-called rich and poor doors.

Does it make sense to you? Listen to a discussion whilst learning some housing-related vocabulary. Fifty years ago, on 18 March , Soviet astronaut Alexei Leonov took the first space walk.

Listen to Rob and Neil describing the struggles of that ground-breaking space mission whilst explaining some related vocabulary. Furniture with built-in wireless charging technology - like a coffee table is now being sold.

So you just pop your phone on the table, and technology does the rest! Many animals face extinction. But people are realising that they must act now to stop further losses.

A scheme to save the Asian elephant in China could provide an answer. How does music make you feel? Coffee is now the most popular drink in the world.

But what about the economics and politics of coffee production? Rob and Neil put on their sunglasses to find out more about this special star and teach some related vocabulary.

The UK has become the first country to approve legislation allowing the creation of babies with genetic material from three people.

An electronic device under your skin?! Workers in Sweden take part in experiment which allows them to get in and out of their office without a key, ID or password.

He is known throughout the world for his role in defeating Nazi Germany but he also made mistakes. We live in a richer world. But the gap between rich and poor is still very wide in individual countries.

How to change this? The price of vaccines has escalated and some poor countries are struggling to prevent children from catching certain life-threatening diseases, says Medecins Sans Frontieres.

Will thinking computers be the end of humans? About 37, tourists are expected to visit Antarctica this season. But should they be going to a region with such a sensitive environment?

At a time when more people compete for fewer jobs, are you sure you present your skills and abilities well to a potential employer?

We use computers for everything nowadays. Are we forgetting our own abilities - and losing our talent? Smoking in cars with children might be banned in England.

Is bullying just an attempt to give a bad name to what is part of human nature? When enemy soldiers sang together in WW1.

Are your pictures, documents and videos safe online? How can science fiction help the world? Rob and Finn discuss a project which aims to inspire through stories of a bright future.

Rob and Finn discuss how to deal with boredom and teach some related vocabulary. The Experiment News Review Courses: Towards Advanced Upper-intermediate Courses: Lower-intermediate English My Way Courses: English In A Minute Feature: English at University English at Work Feature: English at Work News Report Feature: LingoHack 6 Minute English Feature: Drama Words in the News Feature: The Grammar Gameshow Courses: English In A Minute.

English at University Feature: Words in the News. Is music getting faster? Could you be flexitarian? How creative should we be?

We discuss this new term without causing offence! Learn what made people more active in Finland. Why is it becoming so popular?

Are smartphones killing cameras? How intelligent is the octopus? Is technology always the solution? Is gaming a sport? Are you excited about the World Cup?

Why are crowds so quiet these days? Is the internet good or bad?

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